NEXT-GENERATION SEQUENCING ROLE IN PHARMACOGENETICS AND PHARMACOGENOMICS
December 2nd, 2021
Pharmacological response relating to drug response and the adverse effect events varies greatly in different individuals. The importance of assessing the role of inherited variation in genes that affect pharmacokinetics (the absorption, distribution, metabolism and excretion [ADME] of a drug) and pharmacodynamics (the response of the organism to the drug) is becoming more widely recognised (Schwarz, Gulilat and Kim, 2019). Genes involved in the encoding of drug-metabolizing enzymes, drug transporters and drug targets are most commonly referred as pharmacogenes.